You might experience issues with credentials:
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If you specified common credentials for the instance or for discovered virtual machines in the subclient, you might not be able to connect to the guest VM to perform a remote install or to perform the backup. If a specific VM has different credentials, you must add that VM explicitly as subclient content and specify the guest credentials for that VM.
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User credentials are used for the remote installation of application plug-ins and for backups. If application credentials are different from the credentials that were specified to access the virtual machine, the application backup fails.