After deploying Virtual Server Agent (VSA) proxies, you can perform basic configuration to customize your backup and restore operations.
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You must create a virtualization client for the vCenter. If you have multiple vCenters, create a virtualization client for each. 
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Unless you want all virtual machines for the vCenter to be covered by the default subclient, create additional user-defined subclients that identify groups of virtual machines to back up. See Modifying a Subclient for the most important options that you can configure for a subclient. Subclient options enable you to create a client group for each subclient or to identify VM owners automatically. 
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Define rules to discover virtual machines automatically. 
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Define filters to exclude virtual machines based on various criteria. 
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You might want to identify VSA proxies at the subclient level if different subclients have different backup requirements.