When the deduplication is configured in your environment, you can manage the deduplication database by considering the following operations:
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Deduplication Data Consistency To ensure that the CommServe database, deduplication database and data blocks on the disk are synchronized. 
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Move the Deduplication Database To ensure that the deduplication is hosted on the recommended configuration referenced in Deduplication Building Block Guide. 
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Deduplication Database Sealing Seal the deduplication database, when large amount of data on the disk is unreadable due to disk corruption or other hardware issues. 
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Retire Deduplication Database You can retire a deduplication database (DDB) only when the storage policy copy has another DDB associated to the copy apart from the DDB that you plan to retire. The retire operation seals the DDB, but unlike sealing, the retire operation does not create a new DDB. The software automatically prunes the retired DDB with data aging. 
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Restart the Deduplication Database MediaAgent For installing updates or maintenance purposes. 
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Deduplication Tools Tools used to evaluate the performance of the disk hosting the deduplication database. 
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Deduplication Reports Reports to view the status of the deduplication database or deduplication properties. 
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Deduplication Alerts Alerts to notify the status of deduplicated jobs and deduplication database threshold, 
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Performance Tuning Performance tuning parameters can increase efficiency of deduplication by enhancing backup performance.