You can enable ransomware protection on a Windows MediaAgent.
Notes
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For all the Windows MediaAgents that have access to a disk library mount path, ransomware protection is enabled by default. 
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However, for Linux MediaAgents that have access to a disk library mount path, you must enable ransomware protection manually. For instructions, see Ransomware Protection for Disk Libraries on a Linux MediaAgent. 
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If ransomware protection is disabled on Windows MediaAgents that have disk library association, index cache, or deduplication databases, it will be automatically re-enabled after 24 hours. 
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Multi-instancing is supported on Windows MediaAgents. However, both instances must operate on the same Service Pack level to maintain compatibility and system stability. 
Procedure
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From the navigation pane, go to Manage > Infrastructure. The Infrastructure page appears. 
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Click the MediaAgents tile. The MediaAgents page appears. 
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Click the MediaAgent. 
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In the Control section, move the Ransomware protection toggle key to the right. For a Linux MediaAgent, the toggle key is disabled and displays the status of ransomware protection. 
Additional Information
Administrative shares pose a security vulnerability and if you have an existing disk library mount path configured to use an administrative share, reconfigure the share using a dedicated share. For more information, see Reconfiguring Mount Paths that Use Administrative Share.