You can create a network topology instance in which members of either client group can connect to members of the other client group.
Before You Begin
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Verify that the client groups that you want to use in the network topology instance are already defined in the CommCell Console or the Command Center. 
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You must have Administrative Management permissions on the client groups that you plan to use in the network topology instance. 
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Both DMZ servers/infrastructure computers and servers/laptops should be able to open connections to each other on the tunnel port. 
Procedure
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From the Command Center navigation pane, go to Manage > Network > Network Topologies. 
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The Network topologies page appears. 
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Click Add topology. The Add topology dialog box appears. 
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In the Name field, enter a name for this instance of a two-way direct connection. 
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For Client type, select Servers. 
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From the Topology type list, select Two-way. 
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Click Next. 
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From the Servers list, select the server group that will initiate connections with members of the infrastructure computers group. 
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Optional: Click the advanced toggle to edit the following options: - 
Tunnel port. Set this to Default (8403), or enter another port number. 
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Keep-alive interval. The interval (in seconds) for sending keep-alive packets, to maintain the session if backup traffic has an extended pause. Set this to 180 (default), or enter another interval. To avoid idle session timeouts on cloud-based clients, set the interval to 200 seconds or less. 
 
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From the Backup infrastructure list, select the a server group that will initiate connections with members of the Servers group. 
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Optional: To edit the Tunnel port and Keep-alive interval options, as described in Step 9, above. 
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Click Next. 
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Optional: Edit the following advanced options: - 
Move the Encrypt traffic toggle key to the right to encrypt network traffic (HTTPS). 
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Select Encrypted, Authenticated, Regular, or Raw from the tunnel protocol list. 
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Select the Parallel data transfer streams for long distance networks (default value is 1, and maximum value is 8). 
 
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Click Submit.