# Exchange Mailbox User Mailbox Hybrid Environment

Before you set up Exchange Mailbox in the Command Center, perform the prerequisite tasks. After you set up Exchange Mailbox in the Command Center, perform the configuration tasks.

- Prerequisites

- Configurations

## Considerations for Microsoft 365 with Exchange

Consider the following points when you configure your Microsoft 365 with Exchange environment.

### Location of the Access Nodes

The access nodes that run the backup operations must be within the same Active Directory domain.

### Commvault Features That Are Not Supported by Microsoft 365 with Exchange

When the primary mailboxes are on the Exchange On-premises server and the archive mailboxes are on the Exchange Online server, the primary mailboxes are not protected unless you exclude the archive mailboxes from the archiving plan.

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