You might experience issues with credentials:
If you specified common credentials for the hypervisor or for discovered virtual machines in the VM group, you might not be able to connect to the guest VM to perform a remote install or to perform the backup operation. If a specific VM has different credentials, you must add that VM explicitly as VM group content and specify the guest credentials for that VM.
User credentials are used for the remote installation of application plug-ins and for backup operations. If application credentials are different from the credentials that were specified to access the virtual machine, the application backup fails.